abstract：BACKGROUND:Appropriate sedation benefits patients by reducing the stress response, but it requires an appropriate method of assessment to adjust the dosage of sedatives. The aim of this study was to compare the difference in the sedation of mechanically ventilated patients undergoing flexible bronchoscopy (FB) monitore...

journal_title：BMC pulmonary medicine

authors： Hsu CW,Sun SF,Chu KA,Lee DL,Wong KF

更新日期：2014-02-06 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is hallmarked by inflammatory processes and a progressive decline of lung function. YKL-40 is a potential biomarker of inflammation and mortality in patients suffering from inflammatory lung disease, but its prognostic value in patients with COPD remains unknown. ...

journal_title：BMC pulmonary medicine

authors： Holmgaard DB,Mygind LH,Titlestad IL,Madsen H,Pedersen SS,Johansen JS,Pedersen C

更新日期：2013-12-30 00:00:00

abstract：BACKGROUND:The importance of the lung parenchyma in the pathophysiology of asthma has previously been demonstrated. Considering that nitric oxide synthases (NOS) and arginases compete for the same substrate, it is worthwhile to elucidate the effects of complex NOS-arginase dysfunction in the pathophysiology of asthma, ...

journal_title：BMC pulmonary medicine

authors： Aristoteles LR,Righetti RF,Pinheiro NM,Franco RB,Starling CM,da Silva JC,Pigati PA,Caperuto LC,Prado CM,Dolhnikoff M,Martins MA,Leick EA,Tibério IF

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:The six-minute walk test (6MWT) is a simple, low tech, safe and well established, self-paced assessment tool to quantify functional exercise capacity in adults. The definition of normal 6MWT in children is especially demanding since not only parameters like height, weight and ethnical background influence th...

journal_title：BMC pulmonary medicine

authors： Ulrich S,Hildenbrand FF,Treder U,Fischler M,Keusch S,Speich R,Fasnacht M

更新日期：2013-08-05 00:00:00

abstract：BACKGROUND:The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) and the Medical Outcomes Study Short Form 36 (SF-36) are widely used to assess patient-reported outcome in individuals with pulmonary hypertension (PH). The aim of the study was to compare the psychometric properties of the two measures. METHODS:...

journal_title：BMC pulmonary medicine

authors： Twiss J,McKenna S,Ganderton L,Jenkins S,Ben-L'amri M,Gain K,Fowler R,Gabbay E

更新日期：2013-07-12 00:00:00

abstract：BACKGROUND:The aim of this substudy of the ghrelin treatment, multicenter, randomized, double-blind, placebo-controlled trial was to investigate the effects of ghrelin administration on exercise capacity and the underlying mechanisms in underweight patients with chronic obstructive pulmonary disease (COPD) using cardio...

journal_title：BMC pulmonary medicine

authors： Miki K,Maekura R,Nagaya N,Kitada S,Miki M,Yoshimura K,Tateishi Y,Motone M,Hiraga T,Mori M,Kangawa K

更新日期：2013-06-10 00:00:00

abstract：BACKGROUND:Penicillium species are among the most common fungi present in the environment and are usually considered non-pathogenic to humans. However, in immunocompromised hosts they can be virulent pathogens and can cause death. Penicillium digitatum is a plant pathogen that commonly causes a postharvest fungal disea...

journal_title：BMC pulmonary medicine

authors： Oshikata C,Tsurikisawa N,Saito A,Watanabe M,Kamata Y,Tanaka M,Tsuburai T,Mitomi H,Takatori K,Yasueda H,Akiyama K

更新日期：2013-03-23 00:00:00

abstract：BACKGROUND:During the past decades, numerous efforts have been made to decrease the death rate among lung cancer patients. Nonetheless, the improvement in long-term survival has been limited and lung cancer is still a devastating disease. DISCUSSION:With this article we would like to point out that survival of lung ca...

journal_title：BMC pulmonary medicine

authors： Heuvers ME,Hegmans JP,Stricker BH,Aerts JG

更新日期：2012-12-13 00:00:00

abstract：BACKGROUND:Little is known concerning the degree to which initiation of sildenafil for pulmonary arterial hypertension (PAH) impacts patterns of healthcare utilization and costs. METHODS:Using a large US health insurance claims database, we identified all patients with evidence of PAH (ICD-9-CM diagnosis codes 416.0, ...

journal_title：BMC pulmonary medicine

authors： Berger A,Edelsberg J,Teal S,Mychaskiw MA,Oster G

更新日期：2012-12-11 00:00:00

abstract：BACKGROUND:Breathlessness is a common and distressing symptom affecting many patients with advanced disease both from malignant and non-malignant origin. A combination of pharmacological and non-pharmacological measures is necessary to treat this symptom successfully. Breathlessness services in various compositions aim...

journal_title：BMC pulmonary medicine

authors： Bausewein C,Jolley C,Reilly C,Lobo P,Kelly J,Bellas H,Madan P,Panell C,Brink E,De Biase C,Gao W,Murphy C,McCrone P,Moxham J,Higginson IJ

更新日期：2012-09-19 00:00:00

abstract：BACKGROUND:(18)F-FDG PET/CT (PET) is useful in assessing inflammatory activity in sarcoidosis. However, no appropriate indications are available. The aim of this study was to develop a prediction rule that can be used to identify symptomatic sarcoidosis patients who have a high probability of PET-positivity. METHODS:W...

journal_title：BMC pulmonary medicine

authors： Mostard RL,Van Kuijk SM,Verschakelen JA,van Kroonenburgh MJ,Nelemans PJ,Wijnen PA,Drent M

更新日期：2012-09-14 00:00:00

abstract：BACKGROUND:Cystic Fibrosis (CF) is a monogenic disease with complex expression because of the action of genetic and environmental factors. We investigated whether the ACE gene D/I polymorphism is associated with severity of CF. METHODS:A cross-sectional study was performed, from 2009 to 2011, at University of Campinas...

journal_title：BMC pulmonary medicine

authors： Marson FA,Bertuzzo CS,Hortencio TD,Ribeiro JD,Bonadia LC,Ribeiro AF

更新日期：2012-08-08 00:00:00

abstract：BACKGROUND:The evidence regarding the association between lung cancer and occupational exposure to cement is controversial. This study investigated causes of deaths from cancer of respiratory tract among cement workers. METHODS:The deaths of the Greek Cement Workers Compensation Scheme were analyzed covering the perio...

journal_title：BMC pulmonary medicine

authors： Rachiotis G,Drivas S,Kostikas K,Makropoulos V,Hadjichristodoulou C

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND:Exacerbations, a leading cause of hospitalization in patients with chronic obstructive pulmonary disease (COPD), affect the quality of life and prognosis. Treatment recommendations as provided in the evidence-based guidelines are not consistently followed, partly due to absence of simplified task-oriented ap...

journal_title：BMC pulmonary medicine

authors： Ban A,Ismail A,Harun R,Abdul Rahman A,Sulung S,Syed Mohamed A

更新日期：2012-06-22 00:00:00

abstract：BACKGROUND:The tissue factor (TF)-dependent extrinsic pathway has been suggested to be a central mechanism by which the coagulation cascade is locally activated in the lungs of patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS) and thus represents an attractive target for therapeutic int...

journal_title：BMC pulmonary medicine

authors： Morris PE,Steingrub JS,Huang BY,Tang S,Liu PM,Rhode PR,Wong HC

更新日期：2012-02-16 00:00:00

abstract：BACKGROUND:Although patients have more problems using metered dose inhalers, clinical comparisons suggest they provide similar control to dry powder inhalers. Using real-life situations this study was designed to evaluate asthma control in outpatients with moderate to severe persistent asthma and to compare efficacy of...

journal_title：BMC pulmonary medicine

authors： Müller V,Gálffy G,Eszes N,Losonczy G,Bizzi A,Nicolini G,Chrystyn H,Tamási L

更新日期：2011-07-15 00:00:00

abstract：BACKGROUND:US mentholated cigarette sales have increased considerably over 50 years. Preference for mentholated cigarettes is markedly higher in Black people. While menthol itself is not genotoxic or carcinogenic, its acute respiratory effects might affect inhalation of cigarette smoke. This possibility seems consisten...

journal_title：BMC pulmonary medicine

authors： Lee PN

更新日期：2011-04-18 00:00:00

abstract：BACKGROUND:Interleukin-9 (IL-9)-targeted therapies may offer a novel approach for treating asthmatics. Two randomized placebo-controlled studies were conducted to assess the safety profile and potential efficacy of multiple subcutaneous doses of MEDI-528, a humanized anti-IL-9 monoclonal antibody, in asthmatics. METHO...

journal_title：BMC pulmonary medicine

authors： Parker JM,Oh CK,LaForce C,Miller SD,Pearlman DS,Le C,Robbie GJ,White WI,White B,Molfino NA,MEDI-528 Clinical Trials Group.

更新日期：2011-02-28 00:00:00

abstract：BACKGROUND:Pseudomonas aeruginosa infections are associated with progressive life threatening decline of lung function in cystic fibrosis sufferers. Growth of Ps. aeruginosa releases a "grape-like" odour that has been identified as the microbial volatile organic compound 2-aminoacetophenone (2-AA). METHODS:We investig...

journal_title：BMC pulmonary medicine

authors： Scott-Thomas AJ,Syhre M,Pattemore PK,Epton M,Laing R,Pearson J,Chambers ST

更新日期：2010-11-07 00:00:00

abstract：BACKGROUND:Pulmonary surfactant D (SP-D) has important regulatory functions for innate immunity and has been implicated as a biomarker for chronic obstructive pulmonary disease (COPD). We hypothesized that COPD patients would have reduced bronchoalveolar lavage (BAL) fluid SP-D levels compared to healthy smoking and no...

journal_title：BMC pulmonary medicine

authors： Moré JM,Voelker DR,Silveira LJ,Edwards MG,Chan ED,Bowler RP

更新日期：2010-10-25 00:00:00

abstract：BACKGROUND:The ability to objectively differentiate exacerbations of chronic obstructive pulmonary disease (COPD) from day-to-day symptom variations would be an important development in clinical practice and research. We assessed the ability of domiciliary pulse oximetry to achieve this. METHODS:40 patients with moder...

journal_title：BMC pulmonary medicine

authors： Hurst JR,Donaldson GC,Quint JK,Goldring JJ,Patel AR,Wedzicha JA

更新日期：2010-10-20 00:00:00

abstract：BACKGROUND:Despite optimal pharmacological therapy and pulmonary rehabilitation, patients with COPD continue to be breathless. There is a need to develop additional strategies to alleviate symptoms. Learning to sing requires control of breathing and posture and might have benefits that translate into daily life. METHO...

journal_title：BMC pulmonary medicine

authors： Lord VM,Cave P,Hume VJ,Flude EJ,Evans A,Kelly JL,Polkey MI,Hopkinson NS

更新日期：2010-08-03 00:00:00

abstract：BACKGROUND:Liver dysfunction reflects the status of heart failure, with congestion and low perfusion of the liver serving as causative mechanisms. Previous studies demonstrated relationship between the results of liver function test and the prognosis in patients with heart failure. However, few studies have examined th...

journal_title：BMC pulmonary medicine

authors： Takeda Y,Takeda Y,Tomimoto S,Tani T,Narita H,Kimura G

更新日期：2010-04-22 00:00:00

abstract：BACKGROUND:Pulsus paradoxus estimated by dynamic change in area under the oximeter plethysmograph waveform (PEP) might provide a measure of acute asthma severity. Our primary objective was to determine how well PEP correlates with forced expiratory volume in 1-second (%FEV1) (criterion validity) and change of %FEV1 (re...

journal_title：BMC pulmonary medicine

authors： Arnold DH,Jenkins CA,Hartert TV

更新日期：2010-03-29 00:00:00

abstract：BACKGROUND:Smoking cessation is the best possible way to prevent the progression of smoking related airway diseases. However, the effect and time scale of smoking cessation on airway inflammation/remodelling are largely unknown. This prospective study evaluated the effects of smoking cessation on induced sputum (IS) ne...

journal_title：BMC pulmonary medicine

authors： Louhelainen N,Stark H,Mazur W,Rytilä P,Djukanovic R,Kinnula VL

更新日期：2010-03-14 00:00:00

abstract：BACKGROUND:The collection of exhaled breath condensate (EBC) is a suitable and non-invasive method for evaluation of airway inflammation. Several studies indicate that the composition of the condensate and the recovery of biomarkers are affected by physical characteristics of the condensing device and collecting circum...

journal_title：BMC pulmonary medicine

authors： Hoffmeyer F,Raulf-Heimsoth M,Harth V,Bünger J,Brüning T

更新日期：2009-11-30 00:00:00

abstract：BACKGROUND:Cardiac Troponin T (cTnT) elevation during exacerbations of chronic obstructive pulmonary disease (COPD) is associated with increased mortality the first year after hospital discharge. The factors associated with cTnT elevation in COPD are not known. METHODS:From our hospital's database, all patients admitt...

journal_title：BMC pulmonary medicine

authors： Brekke PH,Omland T,Holmedal SH,Smith P,Søyseth V

更新日期：2009-07-19 00:00:00

abstract：BACKGROUND:This study is a cross sectional analysis, aiming to evaluate if atopy is as a risk factor for exercise induced bronchoconstriction (EIB) among Tunisian athletes. METHODS:Atopy was defined by a skin prick test result and EIB was defined as a decrease of at least 15% in forced expiratory volume in one second ...

journal_title：BMC pulmonary medicine

authors： Sallaoui R,Chamari K,Mossa A,Tabka Z,Chtara M,Feki Y,Amri M

更新日期：2009-02-05 00:00:00

abstract：BACKGROUND:The pathological diagnosis of idiopathic interstitial pneumonias (IIP) by surgical lung biopsy is important for clinical decision-making. However, there is a need to use less invasive biomarkers to differentiate nonspecific interstitial pneumonia (NSIP) from other IIP such as usual interstitial pneumonia (UI...

journal_title：BMC pulmonary medicine

authors： Kakugawa T,Yokota S,Mukae H,Kubota H,Sakamoto N,Mizunoe S,Matsuoka Y,Kadota J,Fujii N,Nagata K,Kohno S

更新日期：2008-11-04 00:00:00

abstract：BACKGROUND:The assessment of airway inflammation for the diagnosis of asthma or COPD is still uncommon in pneumology-specialized general practices. In this respect, the measurement of exhaled nitric oxide (NO), as a fast and simple methodology, is increasingly used. The indirect assessment of airway inflammation, howev...

journal_title：BMC pulmonary medicine

authors： Holz O,Seiler T,Karmeier A,Fraedrich J,Leiner H,Magnussen H,Jörres RA,Welker L

更新日期：2008-02-28 00:00:00

abstract：BACKGROUND:As supra-physiological intake of corticosteroids is a well known risk factor for the development of adrenal insufficiency, we investigated the function of the hypothalamic-pituitary-adrenal (HPA) axis during a 14-day course of systemic corticosteroids in patients with acute exacerbation of chronic obstructiv...

journal_title：BMC pulmonary medicine

authors： Schuetz P,Christ-Crain M,Schild U,Süess E,Facompre M,Baty F,Nusbaumer C,Brutsche M,Müller B

更新日期：2008-01-26 00:00:00

abstract：BACKGROUND:Alveolar volume measured according to the American Thoracic Society-European Respiratory Society (ATS-ERS) guidelines during the single breath diffusion test can be underestimated when there is maldistribution of ventilation. Therefore, the alveolar volume calculated by taking into account the ATS-ERS guidel...

journal_title：BMC pulmonary medicine

authors： Prediletto R,Fornai E,Catapano G,Carli C

更新日期：2007-12-19 00:00:00

abstract：BACKGROUND:The outcome of patients with bronchiectasis during and after their stay in the intensive care unit (ICU) has seldom been reported in the literature. Managing these patients in the ICU can be challenging because of the complex nature of their disease. This study aims to identify the in-hospital and long-term ...

journal_title：BMC pulmonary medicine

authors： Alzeer AH,Masood M,Basha SJ,Shaik SA

更新日期：2007-12-10 00:00:00

abstract：BACKGROUND:An understanding of the needs and behaviors of asthma patients is important in developing an asthma-related healthcare policy. The primary goal of the present review was to assess patient perspectives on key issues in asthma and its management, as captured in patient surveys. METHODS:Local, national, and mu...

journal_title：BMC pulmonary medicine

authors： Holgate ST,Price D,Valovirta E

更新日期：2006-11-30 00:00:00

abstract：BACKGROUND:To evaluate the diagnostic accuracy of the integrated Practical Approach to Lung Health in South Africa (PALSA) guideline in identifying patients requiring bacteriological screening for tuberculosis (TB), and to determine which clinical features best predict suspected and bacteriologically-confirmed tubercul...

journal_title：BMC pulmonary medicine

authors： English RG,Bachmann MO,Bateman ED,Zwarenstein MF,Fairall LR,Bheekie A,Majara BP,Lombard C,Scherpbier R,Ottomani SE

更新日期：2006-08-25 00:00:00

abstract：BACKGROUND:The Darlington and Northallerton Asthma Study is an observational cohort study started in 1983. At that time little was published about long term outcome in asthma and the contribution of change in reversible disease or airway remodelling to any excess deterioration in function. The study design included reg...

journal_title：BMC pulmonary medicine

authors： Connolly CK,Prescott RJ

更新日期：2005-01-31 00:00:00

abstract：BACKGROUND:Fine needle aspiration is an important tool for diagnosis and preoperative evaluation of solitary nodules of the lung. It provides a definitive diagnosis in most patients at low cost with minimal trauma. However, because of the nature of the study and the presentation of the cells in a more distorted and inc...

journal_title：BMC pulmonary medicine

authors： Torkian B,Kanthan R,Burbridge B

更新日期：2003-09-08 00:00:00